Influence of ABCB11 and HNF4α genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study

• Published in: Journal of antimicrobial chemotherapy Vol. 72; no. 10; pp. 2846 - 2849
• Main Authors: Cusato, Jessica, De Nicolò, Amedeo, Boglione, Lucio, Favata, Fabio, Ariaudo, Alessandra, Mornese Pinna, Simone, Guido, Federica, Avataneo, Valeria, Carcieri, Chiara, Cariti, Giuseppe, Di Perri, Giovanni, D’Avolio, Antonio
• Format: Journal Article
• Language: English
• Published: England 01.10.2017
• Subjects: Adult; Alleles; Antiviral Agents - blood; Antiviral Agents - therapeutic use; ATP Binding Cassette Subfamily B Member 11 - drug effects; ATP Binding Cassette Subfamily B Member 11 - genetics; Female; Genotype; Hepacivirus - drug effects; Hepatitis C - drug therapy; Hepatitis C - genetics; Hepatitis C - virology; Hepatocyte Nuclear Factor 4 - drug effects; Hepatocyte Nuclear Factor 4 - genetics; Humans; Imidazoles - blood; Imidazoles - therapeutic use; Linear Models; Male; Middle Aged; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction

Daclatasvir is an inhibitor of HCV non-structural 5A protein and is a P-glycoprotein substrate. Pharmacogenetics has had a great impact on previous anti-HCV therapies, particularly considering the association of IL-28B polymorphisms with dual therapy outcome. We investigated the association between...