Affinity of zinc and copper ions for insulin monomers

• Published in: Metallomics Vol. 6; no. 7; p. 1296
• Main Authors: Gavrilova, Julia, Tõugu, Vello, Palumaa, Peep
• Format: Journal Article
• Language: English
• Published: England 01.01.2014
• Subjects: Cations, Divalent - chemistry; Copper - chemistry; HEPES - administration & dosage; Insulin - chemistry; Insulin - metabolism; Kinetics; Protein Binding - drug effects; Protein Structure, Quaternary; Spectrometry, Fluorescence; Zinc - chemistry

Zinc is an essential trace element involved in the correct packing and storage of insulin. Total zinc content in the pancreatic β-cells is among the highest in the body and changes in the Zn(2+) levels have been found to be associated with diabetes. The most common form of the Zn-insulin complex is...