Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

• Published in: Biochemical journal Vol. 473; no. 4; p. 487
• Main Authors: Barlow, Jonathan, Jensen, Verena Hirschberg, Jastroch, Martin, Affourtit, Charles
• Format: Journal Article
• Language: English
• Published: England 15.02.2016
• Subjects: Animals; Cell Line; Female; Glucose - pharmacology; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria - drug effects; Mitochondria - physiology; Palmitic Acid - pharmacology; Type 2 diabetes; pancreatic β-cells; glucolipotoxicity; mitochondria; obesity; oxidative phosphorylation

It has been well established that excessive levels of glucose and palmitate lower glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells. This β-cell 'glucolipotoxicity' is possibly mediated by mitochondrial dysfunction, but involvement of bioenergetic failure in the pathologica...