Anti-HLA Antibodies After Precocious Transplantectomy by Vascular Thrombosis
Our objective in this study was to determine the effects of early renal transplantectomy on patients and the production of anti–human leukocyte antigen (anti-HLA) antibodies. Between January 2003 and May 2017, we analyzed a group of patients for the presence of specific HLA class I and/or II donor-s...
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Published in | Transplantation proceedings Vol. 50; no. 2; pp. 546 - 549 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.03.2018
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Online Access | Get full text |
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Summary: | Our objective in this study was to determine the effects of early renal transplantectomy on patients and the production of anti–human leukocyte antigen (anti-HLA) antibodies.
Between January 2003 and May 2017, we analyzed a group of patients for the presence of specific HLA class I and/or II donor-specific antibodies (DSA), their panel-reactive antibodies (PRA), and the time period in which the antibodies were still detectable after transplantectomy.
Anti-HLA antibodies were detected in 60.8% of patients, 60.8% and 52.2% of those patients had anti-class I and anti-class II antibodies, respectively. DSA were detected in 91.7% of the anti–HLA class I patients. Class II DSA were detected all of the patients with anti–HLA class II antibodies. The average (mean ± SD) PRA levels in our patients after transplantectomy was 60 ± 34% in class I and 63 ± 36% in class II.
Anti-HLA antibodies can be detected well after transplantectomy. Even if the kidney allograft had been transplanted for only a short time, when the intensity of immunosuppression was the highest, many patients developed anti-HLA antibodies. The patients who continued with immunosuppression after transplantectomy did not develop anti-HLA antibodies. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0041-1345 1873-2623 |
DOI: | 10.1016/j.transproceed.2018.01.002 |