Muscular metabolism during oxygen supplementation in patients with chronic hypoxemia

• Published in: The American review of respiratory disease Vol. 147; no. 3; p. 592
• Main Authors: Payen, J F, Wuyam, B, Levy, P, Reutenauer, H, Stieglitz, P, Paramelle, B, Le Bas, J F
• Format: Journal Article
• Language: English
• Published: United States 01.03.1993
• Subjects: Aged; Analysis of Variance; Chronic Disease; Exercise - physiology; Exercise Test - statistics & numerical data; Humans; Hydrogen-Ion Concentration; Hypoxia - epidemiology; Hypoxia - etiology; Hypoxia - metabolism; Hypoxia - therapy; Lung Diseases, Obstructive - complications; Lung Diseases, Obstructive - epidemiology; Lung Diseases, Obstructive - metabolism; Lung Diseases, Obstructive - therapy; Magnetic Resonance Spectroscopy - instrumentation; Magnetic Resonance Spectroscopy - methods; Male; Middle Aged; Muscles - metabolism; Oxygen Inhalation Therapy; Phosphates - metabolism

The effects of supplemental oxygen (O2) versus air on working calf muscle metabolism were studied in seven patients with stable chronic obstructive pulmonary disease (COPD) and chronic hypoxemia (PaO2 = 57 +/- 3 SE mm Hg) and seven age-matched control subjects. Oxygen and air were randomly administr...