Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors

• Published in: Human molecular genetics Vol. 23; no. 22; pp. 5989 - 5997
• Main Authors: Becirovic, Elvir, Nguyen, O N Phuong, Paparizos, Christos, Butz, Elisabeth S, Stern-Schneider, Gabi, Wolfrum, Uwe, Hauck, Stefanie M, Ueffing, Marius, Wahl-Schott, Christian, Michalakis, Stylianos, Biel, Martin
• Format: Journal Article
• Language: English
• Published: England 15.11.2014
• Subjects: Animals; Cyclic Nucleotide-Gated Cation Channels - genetics; Cyclic Nucleotide-Gated Cation Channels - metabolism; Humans; Mice; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Peripherins - genetics; Peripherins - metabolism; Protein Binding; Protein Structure, Tertiary; Retina - metabolism; Retinal Photoreceptor Cell Outer Segment - metabolism; Retinal Rod Photoreceptor Cells - metabolism; Retinitis Pigmentosa - genetics; Retinitis Pigmentosa - metabolism; Rhodopsin - genetics; Rhodopsin - metabolism

Outer segments (OSs) of rod photoreceptors are cellular compartments specialized in the conversion of light into electrical signals. This process relies on the light-triggered change in the intracellular levels of cyclic guanosine monophosphate, which in turn controls the activity of cyclic nucleoti...