Estradiol and progesterone-induced slowing of gonadotropin-releasing hormone pulse frequency is not reversed by subsequent administration of mifepristone

• Published in: Endocrine Vol. 36; no. 2; pp. 239 - 245
• Main Authors: McCartney, Christopher R., Blank, Susan K., Marshall, John C.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2009
• Subjects: Adult; Circadian Rhythm - physiology; Diabetes; Drug Administration Routes; Drug Administration Schedule; Endocrinology; Estradiol - administration & dosage; Estradiol - adverse effects; Estradiol - pharmacology; Female; Follicle Stimulating Hormone - blood; Gonadotropin-Releasing Hormone - blood; Gonadotropin-Releasing Hormone - metabolism; Hormone Antagonists - administration & dosage; Hormone Antagonists - adverse effects; Hormone Antagonists - pharmacology; Humanities and Social Sciences; Humans; Internal Medicine; Luteinizing Hormone - blood; Medicine; Medicine & Public Health; Mifepristone - administration & dosage; Mifepristone - adverse effects; Mifepristone - pharmacology; multidisciplinary; Original Paper; Progesterone - administration & dosage; Progesterone - adverse effects; Progesterone - pharmacology; Pulsatile Flow - drug effects; Science; Young Adult; Luteinizing hormone; Luteal-follicular transition; Mifepristone; Gonadotropin-releasing hormone; Progesterone; Estradiol

Subsequent to suppression of LH (GnRH) pulse frequency by progesterone (P) and estradiol (E 2 ), LH pulse frequency remains slow for 7 days after P withdrawal if mid-luteal E 2 concentrations are maintained. This may reflect an ability of E 2 to potentiate the suppressive effects of low P levels. We...