Allosteric LFA-1 Inhibitors Modulate Natural Killer Cell Function

• Published in: Molecular pharmacology Vol. 75; no. 2; pp. 355 - 362
• Main Authors: Gabriele Weitz-Schmidt, Stéphanie Chreng, Simone Riek
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.02.2009
• Subjects: Biophysical Phenomena; Cell Adhesion - drug effects; Cell Adhesion - physiology; Humans; K562 Cells; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Killer Cells, Natural - physiology; Lymphocyte Function-Associated Antigen-1 - drug effects; Lymphocyte Function-Associated Antigen-1 - metabolism; Lymphocyte Function-Associated Antigen-1 - physiology; Signal Transduction - physiology

Natural killer (NK) cells are believed to play an important role in a variety of disease pathologies, including transplant rejection and autoimmunity. None of the therapeutic modalities currently available are known to potently interfere with NK cell activity. Here we demonstrate for the first time...