FGF8 induces chemokinesis and regulates condensation of mouse nephron progenitor cells

• Published in: Development (Cambridge) Vol. 149; no. 21
• Main Authors: Sharma, Abhishek, Meer, Marco, Dapkunas, Arvydas, Ihermann-Hella, Anneliis, Kuure, Satu, Vainio, Seppo J, Iber, Dagmar, Naillat, Florence
• Format: Journal Article
• Language: English
• Published: England 01.11.2022
• Subjects: Animals; Fibroblast Growth Factor 8 - genetics; Fibroblast Growth Factor 8 - metabolism; Fibroblast Growth Factors - metabolism; Kidney - metabolism; Mice; Mice, Transgenic; Nephrons - metabolism; Organogenesis; Stem Cells - metabolism; Computing modelling; Nephron progenitor cells; Condensation step; Kidney development

Kidneys develop via iterative branching of the ureteric epithelial tree and subsequent nephrogenesis at the branch points. Nephrons form in the cap mesenchyme as the metanephric mesenchyme (MM) condenses around the epithelial ureteric buds (UBs). Previous work has demonstrated that FGF8 is important...