Age reprogramming: cell rejuvenation by partial reprogramming

• Published in: Development (Cambridge) Vol. 149; no. 22
• Main Authors: Singh, Prim B., Zhakupova, Assem
• Format: Journal Article
• Language: English
• Published: England 15.11.2022
• Subjects: Cellular Reprogramming - genetics; Epigenesis, Genetic; Induced Pluripotent Stem Cells; Regenerative Medicine; Rejuvenation; Epigenetic rejuvenation; OSKM; Cellular identity; Partial reprogramming; H3K9me3; Age reprogramming

‘Age reprogramming’ refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated without passage through an embryonic stage. This process differs from the rejuvenation observed in differentiated derivatives of induced pluripoten...