Crushing of dolutegravir fixed-dose combination tablets increases dolutegravir exposure

If HIV patients are unconscious or cannot swallow tablets for other reasons, antiretroviral medication is crushed and dissolved prior to administration. Crushing can alter drug exposure, possibly leading to treatment failure, development of resistance or toxicity. Currently, there is no information...

Full description

Saved in:
Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 73; no. 9; pp. 2430 - 2434
Main Authors Roskam-Kwint, Marieke, Bollen, Pauline, Colbers, Angela, Duisenberg-van Essenberg, Marjolijn, Harbers, Veroniek, Burger, David
Format Journal Article
LanguageEnglish
Published England 01.09.2018
Online AccessGet full text
ISSN0305-7453
1460-2091
1460-2091
DOI10.1093/jac/dky191

Cover