High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction

• Published in: Neurobiology of learning and memory Vol. 128; pp. 17 - 22
• Main Authors: Kutlu, Munir Gunes, Holliday, Erica, Gould, Thomas J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2016
• Subjects: alpha7 Nicotinic Acetylcholine Receptor - genetics; alpha7 Nicotinic Acetylcholine Receptor - physiology; Animals; Extinction; Extinction, Psychological - drug effects; Extinction, Psychological - physiology; Fear - drug effects; Fear - physiology; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotine - administration & dosage; Nicotinic receptors; Protein Subunits - genetics; Protein Subunits - physiology; PTSD; Receptors, Nicotinic - genetics; Receptors, Nicotinic - physiology; PTSD; Nicotinic receptors; Extinction; Nicotine
• ISSN: 1074-7427; 1095-9564; 1095-9564
• DOI: 10.1016/j.nlm.2015.11.021

Previously, studies from our lab have shown that while acute nicotine administered prior to training and testing enhances contextual fear conditioning, acute nicotine injections prior to extinction sessions impair extinction of contextual fear. Although there is also strong evidence showing that the...