Successful Live Birth Following Natural Cycle Oocyte Retrieval in a Woman with Primary Infertility and Atypical Primary Ovarian Insufficiency with a DNAH1 Gene Deletion Mutation

• Published in: Genetic testing and molecular biomarkers Vol. 25; no. 10; p. 668
• Main Authors: Liu, Min, Huang, Shan, Zhao, Xiangyu, Wu, Fengxia, Zhu, Dongyi, Zhai, Xianghong, Wang, Ancong
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Adult; DNA Mutational Analysis; Dyneins - genetics; Female; Fertilization in Vitro - methods; Gene Deletion; Humans; Infertility, Female - diagnosis; Infertility, Female - genetics; Infertility, Female - therapy; Live Birth; Male; Oocyte Retrieval - methods; Primary Ovarian Insufficiency - complications; Primary Ovarian Insufficiency - diagnosis; Primary Ovarian Insufficiency - genetics; Primary Ovarian Insufficiency - therapy; Treatment Outcome; Whole Exome Sequencing; primary ovarian insufficiency; DNAH1 gene; infertility; primary ciliary dyskinesia; resistant ovary syndrome
• ISSN: 1945-0257
• DOI: 10.1089/gtmb.2020.0303

Dynein, axonemal, heavy chain 1 ( ) gene mutations have been found to be related to primary ciliary dyskinesia (PCD) and the gene is associated with abnormal flagellar morphology in spermatozoa. Infertility is a common condition in women presenting with primary ovarian insufficiency (POI) characteri...