PTP1B Inhibitory Flavonoids From Orthosiphon stamineus Benth. and Their Growth Inhibition on Human Breast Cancer Cells

• Published in: Natural product communications Vol. 15; no. 1; p. 1934578
• Main Authors: To, Dao-Cuong, Hoang, Duc-Thuan, Tran, Manh-Hung, Pham, Minh-Quan, Huynh, Nhu-Tuan, Nguyen, Phi-Hung
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2020
• Subjects: breast cancer; Orthosiphon stamineus; Lamiaceae; PTP1B; flavonoid; cytotoxicity

In our preliminary screening study on the protein tyrosine phosphatase 1B (PTP1B) inhibitory and cytotoxic activities, an ethyl acetate soluble fraction of the aerial part of Orthosiphon stamineus Benth. was found to inhibit PTP1B activity. Thus, based on assay-guided isolation of this active fracti...