Background changing patterns of neonatal fungal sepsis in a developing country

• Published in: Journal of tropical pediatrics (1980) Vol. 59; no. 6; p. 460
• Main Authors: Ballot, Daynia E, Bosman, Noma, Nana, Trusha, Ramdin, Tanisha, Cooper, Peter A
• Format: Journal Article
• Language: English
• Published: England 01.12.2013
• Subjects: Antifungal Agents - pharmacology; Antifungal Agents - therapeutic use; Birth Weight; Candida - classification; Candida - drug effects; Candida - isolation & purification; Candidemia - diagnosis; Candidemia - drug therapy; Candidemia - epidemiology; Candidemia - microbiology; Candidiasis - diagnosis; Candidiasis - drug therapy; Candidiasis - microbiology; Candidiasis - mortality; Drug Resistance, Fungal; Female; Fluconazole - pharmacology; Fluconazole - therapeutic use; Humans; Incidence; Infant, Newborn; Male; Microbial Sensitivity Tests; Pyrimidines - pharmacology; Pyrimidines - therapeutic use; Risk Factors; Socioeconomic Factors; South Africa - epidemiology; Treatment Outcome; Triazoles - pharmacology; Triazoles - therapeutic use; Voriconazole; South Africa; fungal sepsis; fungal bloodstream infections; neonates; Candida

Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. To determine the predominant organisms, antifungal sensitivity patterns, clinical and demographic risk factors and crude mortality rate in neonatal...