Background changing patterns of neonatal fungal sepsis in a developing country

Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. To determine the predominant organisms, antifungal sensitivity patterns, clinical and demographic risk factors and crude mortality rate in neonatal...

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Published inJournal of tropical pediatrics (1980) Vol. 59; no. 6; p. 460
Main Authors Ballot, Daynia E, Bosman, Noma, Nana, Trusha, Ramdin, Tanisha, Cooper, Peter A
Format Journal Article
LanguageEnglish
Published England 01.12.2013
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Abstract Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. To determine the predominant organisms, antifungal sensitivity patterns, clinical and demographic risk factors and crude mortality rate in neonatal fungal BSI cases. This is a review of all neonatal fungal BSI cases between January 2007 and December 2011. Fifty-nine patients were included in the study. Candida parapsilosis (54.2%) was isolated in majority of the cases, followed by C. albicans (27.1%). Fluconazole resistance was present in 16 of 32 cases of C. parapsilosis versus 1 of 16 cases of C. albicans (P = 0.003). Mortality rate was 45.8%. Surgical problems were present in 55.9%. Death was significantly associated with lower birth weight (P = 0.046) and necrotizing enterocolitis (P = 0.034). The increase in neonatal fungal BSI and resistant organisms highlights the need to review use of routine empiric fluconazole and to implement preventive measures.
AbstractList Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. To determine the predominant organisms, antifungal sensitivity patterns, clinical and demographic risk factors and crude mortality rate in neonatal fungal BSI cases. This is a review of all neonatal fungal BSI cases between January 2007 and December 2011. Fifty-nine patients were included in the study. Candida parapsilosis (54.2%) was isolated in majority of the cases, followed by C. albicans (27.1%). Fluconazole resistance was present in 16 of 32 cases of C. parapsilosis versus 1 of 16 cases of C. albicans (P = 0.003). Mortality rate was 45.8%. Surgical problems were present in 55.9%. Death was significantly associated with lower birth weight (P = 0.046) and necrotizing enterocolitis (P = 0.034). The increase in neonatal fungal BSI and resistant organisms highlights the need to review use of routine empiric fluconazole and to implement preventive measures.
Author Ramdin, Tanisha
Cooper, Peter A
Nana, Trusha
Ballot, Daynia E
Bosman, Noma
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Issue 6
Keywords fungal sepsis
fungal bloodstream infections
neonates
Candida
Language English
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Snippet Candida albicans is the predominant isolate in many neonatal fungal bloodstream infections (BSIs), so fluconazole is used as empiric antifungal therapy. To...
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StartPage 460
SubjectTerms Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Birth Weight
Candida - classification
Candida - drug effects
Candida - isolation & purification
Candidemia - diagnosis
Candidemia - drug therapy
Candidemia - epidemiology
Candidemia - microbiology
Candidiasis - diagnosis
Candidiasis - drug therapy
Candidiasis - microbiology
Candidiasis - mortality
Drug Resistance, Fungal
Female
Fluconazole - pharmacology
Fluconazole - therapeutic use
Humans
Incidence
Infant, Newborn
Male
Microbial Sensitivity Tests
Pyrimidines - pharmacology
Pyrimidines - therapeutic use
Risk Factors
Socioeconomic Factors
South Africa - epidemiology
Treatment Outcome
Triazoles - pharmacology
Triazoles - therapeutic use
Voriconazole
Title Background changing patterns of neonatal fungal sepsis in a developing country
URI https://www.ncbi.nlm.nih.gov/pubmed/23803724
Volume 59
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