Invariom based electron density studies on the C/Si analogues haloperidol/sila-haloperidol and venlafaxine/sila-venlafaxine

• Published in: Organic & biomolecular chemistry Vol. 13; no. 34; pp. 9093 - 9106
• Main Authors: Luger, Peter, Dittrich, Birger, Tacke, Reinhold
• Format: Journal Article
• Language: English
• Published: England 14.09.2015
• Subjects: Carbon - chemistry; Electrons; Haloperidol - analogs & derivatives; Haloperidol - chemistry; Models, Molecular; Molecular Structure; Organosilicon Compounds - chemistry; Quantum Theory; Silicon - chemistry; Stereoisomerism; Venlafaxine Hydrochloride - chemistry

The subjects of this study are the structures and electron densities of the carbon/silicon analogues haloperidol/sila-haloperidol ( 1a / 1b ) and venlafaxine/sila-venlafaxine ( 2a / 2b ). The parent carbon compounds 1a (an antipsychotic agent) and 2a (an antidepressant) are both in clinical use. For...