Low Ctr1p, due to lack of Sco1p results in lowered cisplatin uptake and mediates insensitivity of rho0 yeast to cisplatin

• Published in: Journal of inorganic biochemistry Vol. 187; pp. 14 - 24
• Main Authors: Bodiga, Sreedhar, Vemuri, Praveen Kumar, Bodiga, Vijaya Lakshmi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018
• Subjects: Cisplatin; Copper; Ctr1; Mitochondria; Rho0; Sco1; Ctr1; Rho0; Mitochondria; Copper; Sco1; Cisplatin

Copper and cisplatin share copper transporter 1 (Ctr1) for cellular import. Copper depletion increases sensitivity of wild type yeast to cisplatin, whereas mitochondrial DNA-deficient rho0 cells are resistant to cisplatin. In the current study, we sought to determine whether copper deprivation modul...