Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type β-lactamase, involved in a large outbreak in a neonatal intensive care unit

• Published in: Journal of antimicrobial chemotherapy Vol. 69; no. 10; pp. 2620 - 2624
• Main Authors: Di Pilato, Vincenzo, Arena, Fabio, Giani, Tommaso, Conte, Viola, Cresti, Stefania, Rossolini, Gian Maria
• Format: Journal Article
• Language: English
• Published: England 01.10.2014
• Subjects: Bacterial Proteins - genetics; Base Sequence; beta-Lactamases - genetics; Conjugation, Genetic; Cross Infection; Disease Outbreaks; DNA Transposable Elements; Gene Order; Humans; Integrons; Intensive Care Units, Neonatal; Klebsiella Infections - microbiology; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Molecular Sequence Data; Plasmids - genetics; FOX-type β-lactamase; class C β-lactamases; transposons; Gram-negative

FOX-type enzymes are a lineage of AmpC-type β-lactamases from Aeromonas spp. whose genes have been mobilized to plasmids spreading among Enterobacteriaceae, where they can be responsible for resistance to extended-spectrum cephalosporins and β-lactamase inhibitor combinations. Little is known about...