Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay

• Published in: Genetic testing and molecular biomarkers Vol. 22; no. 4; p. 266
• Main Authors: Langaee, Taimour, Wagner, Richard, Horne, Lloyd P, Lawson, Lee Ann, Becker, Cecilia, Shahin, Mohamed, Starostik, Petr, Stacpoole, Peter W
• Format: Journal Article
• Language: English
• Published: United States 01.04.2018
• Subjects: GSTZ1; dichloroacetate (DCA); haplotype; pharmacokinetic; pharmacogenetics

Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1). Variation in the GSTZ1 haplotype is the principal variable influencing DCA kinetics and dynamics in humans. We aimed to develop a sen...