Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance

• Published in: Journal of cell science Vol. 127; no. Pt 16; pp. 3578 - 3592
• Main Authors: Molt, Sibylle, Bührdel, John B, Yakovlev, Sergiy, Schein, Peter, Orfanos, Zacharias, Kirfel, Gregor, Winter, Lilli, Wiche, Gerhard, van der Ven, Peter F M, Rottbauer, Wolfgang, Just, Steffen, Belkin, Alexey M, Fürst, Dieter O
• Format: Journal Article
• Language: English
• Published: England 15.08.2014
• Subjects: Animals; Cell Line; Cells, Cultured; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Filamins - genetics; Filamins - metabolism; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Myoblasts - metabolism; Myofibrils - genetics; Myofibrils - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Phosphoglucomutase - genetics; Phosphoglucomutase - metabolism; Protein Binding; Aciculin; XIRP1; Myofibrillogenesis; PGM5; Striated muscle; Xin actin-binding repeat-containing protein; Phosphoglucomutase

Filamin C (FLNc) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adaptor proteins that are mainly expressed in cardiac and skeletal muscles and which play important roles in the assembly and repair of myofibrils and their attachment to the membrane. We identified the dystrophin-bi...