Immunohistochemical analysis of HNF4A and β-catenin expression to predict low-grade dysplasia in the colitis-neoplastic sequence

• Published in: Acta biochimica et biophysica Sinica Vol. 53; no. 1; pp. 94 - 101
• Main Authors: He, Yiping, Chen, Lezong, Chen, Ke, Sun, Yunwei
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 12.01.2021
• Subjects: β-catenin; hepatocyte nuclear factor 4 alpha; cytoskeleton; colitis-associated neoplasm

Abstract Animal studies indicated that P1 promoter–driven hepatocyte nuclear factor 4 alpha (HFN4A) prevents carcinogenesis in colitis. But the function of total HNF4A protein has not been fully investigated, and it was assumed to be involved in the colitis-neoplastic sequence. The aim of this study...