Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives
A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a...
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Published in | Organic & biomolecular chemistry Vol. 13; no. 6; pp. 1634 - 1638 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
14.02.2015
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Subjects | |
Online Access | Get full text |
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Summary: | A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a membrane-based phase separation module. The wider applicability of our setup was demonstrated with the synthesis of nine protected cyanohydrin derivatives, all obtained in good yields and high to excellent enantioselectivity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c4ob02128b |