Direct and indirect control of Rho-dependent transcription termination by the Escherichia coli lysC riboswitch
Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The riboswitch has been previously shown to regulate gene expression through translation initiation and mRNA decay. Recent research suggests that gene expression is a...
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Published in | RNA (Cambridge) Vol. 30; no. 4; pp. 381 - 391 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Cold Spring Harbor Laboratory Press
01.04.2024
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Abstract | Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The
riboswitch has been previously shown to regulate gene expression through translation initiation and mRNA decay. Recent research suggests that
gene expression is also influenced by Rho-dependent transcription termination. Through a series of in silico, in vitro, and in vivo experiments, we provide experimental evidence that the
riboswitch directly and indirectly modulates Rho transcription termination. Our study demonstrates that Rho-dependent transcription termination plays a significant role in the cotranscriptional regulation of
expression. Together with previous studies, our work suggests that
expression is governed by a lysine-sensing riboswitch that regulates translation initiation, transcription termination, and mRNA degradation. Notably, both Rho and RNase E target the same region of the RNA molecule, implying that RNase E may degrade Rho-terminated transcripts, providing a means to selectively eliminate these incomplete messenger RNAs. Overall, this study sheds light on the complex regulatory mechanisms used by bacterial riboswitches, emphasizing the role of transcription termination in the control of gene expression and mRNA stability. |
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AbstractList | Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The
Escherichia coli lysC
riboswitch has been previously shown to regulate gene expression through translation initiation and mRNA decay. Recent research suggests that
lysC
gene expression is also influenced by Rho-dependent transcription termination. Through a series of in silico, in vitro, and in vivo experiments, we provide experimental evidence that the
lysC
riboswitch directly and indirectly modulates Rho transcription termination. Our study demonstrates that Rho-dependent transcription termination plays a significant role in the cotranscriptional regulation of
lysC
expression. Together with previous studies, our work suggests that
lysC
expression is governed by a lysine-sensing riboswitch that regulates translation initiation, transcription termination, and mRNA degradation. Notably, both Rho and RNase E target the same region of the RNA molecule, implying that RNase E may degrade Rho-terminated transcripts, providing a means to selectively eliminate these incomplete messenger RNAs. Overall, this study sheds light on the complex regulatory mechanisms used by bacterial riboswitches, emphasizing the role of transcription termination in the control of gene expression and mRNA stability. Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The riboswitch has been previously shown to regulate gene expression through translation initiation and mRNA decay. Recent research suggests that gene expression is also influenced by Rho-dependent transcription termination. Through a series of in silico, in vitro, and in vivo experiments, we provide experimental evidence that the riboswitch directly and indirectly modulates Rho transcription termination. Our study demonstrates that Rho-dependent transcription termination plays a significant role in the cotranscriptional regulation of expression. Together with previous studies, our work suggests that expression is governed by a lysine-sensing riboswitch that regulates translation initiation, transcription termination, and mRNA degradation. Notably, both Rho and RNase E target the same region of the RNA molecule, implying that RNase E may degrade Rho-terminated transcripts, providing a means to selectively eliminate these incomplete messenger RNAs. Overall, this study sheds light on the complex regulatory mechanisms used by bacterial riboswitches, emphasizing the role of transcription termination in the control of gene expression and mRNA stability. Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The Escherichia coli lysC riboswitch has been previously shown to regulate gene expression through translation initiation and mRNA decay. Recent research suggests that lysC gene expression is also influenced by Rho-dependent transcription termination. Through a series of in silico, in vitro, and in vivo experiments, we provide experimental evidence that the lysC riboswitch directly and indirectly modulates Rho transcription termination. Our study demonstrates that Rho-dependent transcription termination plays a significant role in the cotranscriptional regulation of lysC expression. Together with previous studies, our work suggests that lysC expression is governed by a lysine-sensing riboswitch that regulates translation initiation, transcription termination, and mRNA degradation. Notably, both Rho and RNase E target the same region of the RNA molecule, implying that RNase E may degrade Rho-terminated transcripts, providing a means to selectively eliminate these incomplete messenger RNAs. Overall, this study sheds light on the complex regulatory mechanisms used by bacterial riboswitches, emphasizing the role of transcription termination in the control of gene expression and mRNA stability. |
Author | Côté, Jean Phillippe Korepanov, Alexey P Ghosh, Tithi Chauvier, Adrien Jahangirnejad, Shirin Stringer, Anne M Wade, Joseph T Lafontaine, Daniel A |
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Keywords | lysine riboswitch reporter gene assays Rho-dependent transcription termination |
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Snippet | Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The
riboswitch has been... Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The Escherichia coli lysC... Bacterial riboswitches are molecular structures that play a crucial role in controlling gene expression to maintain cellular balance. The Escherichia coli lysC... |
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SubjectTerms | Bacteria - genetics Base Sequence E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Gene expression Gene Expression Regulation, Bacterial mRNA stability mRNA turnover Ribonuclease E Riboswitch - genetics Riboswitches RNA, Bacterial - metabolism Transcription initiation Transcription termination Transcription, Genetic Translation initiation Translation termination |
Title | Direct and indirect control of Rho-dependent transcription termination by the Escherichia coli lysC riboswitch |
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