Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in healthy human subjects

• Published in: European journal of nuclear medicine Vol. 29; no. 2; pp. 183 - 190
• Main Authors: Fujita, Masahiro, Seibyl, John P., Vaupel, Bruce D., Tamagnan, Gilles, Early, Michele, Zoghbi, Sami S., Baldwin, Ronald M., Horti, Andrew G., Koren, Andrei O., Mukhin, Alexey G., Khan, Shaukat, Bozkurt, Ali, Kimes, Alane S., London, Edythe D., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.02.2002; Springer Nature B.V
• Subjects: Adult; Azetidines - pharmacokinetics; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Contrast media. Radiopharmaceuticals; Female; Humans; Iodine Radioisotopes - pharmacokinetics; Male; Medical sciences; Pharmacology. Drug treatments; Pyridines - pharmacokinetics; Radiation Dosage; Radiopharmaceuticals - pharmacokinetics; Receptors, Nicotinic - metabolism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Radionuclide study; Human; Biology; Pharmacology; Radioisotope; Radiation absorption; Radiation dose; Distribution; Whole body; Dosimetry; Radiopharmaceuticals; Brain (vertebrata); Iodine ion; Positron; Emission tomography

The biodistribution of radioactivity after the administration of a new tracer for alpha4beta2 nicotinic acetylcholine receptors (nAChRs), [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380), was studied in ten healthy human subjects. Following administration of 98+/-6 MBq [123I]5-I-A-853...