Enhanced antibacterial nanocomposite mats by coaxial electrospinning of polycaprolactone fibers loaded with Zn-based nanoparticles

• Published in: Nanomedicine Vol. 14; no. 5; pp. 1695 - 1706
• Main Authors: Prado-Prone, Gina, Silva-Bermudez, Phaedra, Almaguer-Flores, Argelia, García-Macedo, Jorge A., García, Victor I., Rodil, Sandra E., Ibarra, Clemente, Velasquillo, Cristina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2018
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - chemistry; Antibacterial nanocomposites; Bandages; Coaxial electrospinning; Escherichia coli - drug effects; Escherichia coli - growth & development; Nanofibers - administration & dosage; Nanofibers - chemistry; Nanotechnology; Polycaprolactone; Polyesters - chemistry; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Zinc Acetate - administration & dosage; Zinc Acetate - chemistry; Zinc Oxide - administration & dosage; Zinc Oxide - chemistry; Zn acetate; ZnO nanoparticles; Antibacterial nanocomposites; ZnO nanoparticles; Zn acetate; Polycaprolactone; Coaxial electrospinning

ZnO and Zn acetate nanoparticles were embedded in polycaprolactone coaxial-fibers and uniaxial-fibers matrices to develop potential antibacterial nanocomposite wound dressings (mats). Morphology, composition, wettability, crystallinity and fiber structure of mats were characterized. Antibacterial pr...