Glucose-lowering drugs in patients with chronic kidney disease: a narrative review on pharmacokinetic properties

• Published in: Nephrology, dialysis, transplantation Vol. 29; no. 7; pp. 1284 - 1300
• Main Authors: Arnouts, P., Bolignano, D., Nistor, I., Bilo, H., Gnudi, L., Heaf, J., Biesen, W. v.
• Format: Journal Article
• Language: English
• Published: England 01.07.2014
• Subjects: Blood Glucose - metabolism; Humans; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - therapeutic use; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Tissue Distribution; dialysis; pharmacokinetics; chronic kidney disease; glucose lowering drugs; diabetes

The achievement of a good glycaemic control is one of the cornerstones for preventing and delaying progression of microvascular and macrovascular complications in patients with both diabetes and chronic kidney disease (CKD). As for other drugs, the presence of an impaired renal function may signific...