CIIA negatively regulates the Ras-Erk1/2 signaling pathway through inhibiting the Ras-specific GEF activity of SOS1

• Published in: Journal of cell science Vol. 127; no. Pt 8; pp. 1640 - 1646
• Main Authors: Hwang, Hyun Sub, Hwang, Sang Gil, Yoon, Kyoung-Wan, Yoon, Je-Hyun, Roh, Kyung-Hye, Choi, Eui-Ju
• Format: Journal Article
• Language: English
• Published: England 15.04.2014
• Subjects: Animals; Cyclin D1 - genetics; Cyclin D1 - metabolism; DNA Replication; Dogs; Endosomal Sorting Complexes Required for Transport - physiology; Epidermal Growth Factor - physiology; Extracellular Signal-Regulated MAP Kinases - metabolism; Guanine Nucleotide Exchange Factors - physiology; HEK293 Cells; HeLa Cells; Humans; Madin Darby Canine Kidney Cells; MAP Kinase Signaling System; Mice; Mutation, Missense; NIH 3T3 Cells; Noonan Syndrome - genetics; ras Proteins - metabolism; SOS1 Protein - physiology; CIIA; SOS1; Ras; VPS28

Son of sevenless 1 (SOS1) is a Ras-specific guanine-nucleotide-exchange factor (GEF) that mediates intracellular signaling processes induced by receptor tyrosine kinases. In this study, we show that CIIA (also known as VPS28) physically associates with SOS1 and thereby inhibits the GEF activity of S...