Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 37; p. e2300078
• Main Authors: He, Shiliang, Jia, Xiao, Feng, Sai, Hu, Junqing
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2023
• Subjects: Hydrogen peroxide; Hypoxia; Infrared absorption; Nanoparticles; Nanotechnology; Near infrared radiation; Side effects; Tumors; theranostics; tumor microenvironments; photothermal therapies; photodynamic therapies; phototherapies

Canonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H 2 O 2 , GSH, and proteases. To overcome the short...