Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells

• Published in: Clinical science (1979) Vol. 131; no. 15; pp. 1801 - 1814
• Main Authors: Steinbach, Sarah K., Yau, Terrence M., Ouzounian, Maral, Abdel-Qadir, Husam, Chandy, Mark, Waddell, Thomas K., Husain, Mansoor
• Format: Journal Article
• Language: English
• Published: England 01.08.2017
• Subjects: Aged; Biopsy; Calcium - metabolism; Cell Differentiation - physiology; Cells, Cultured; Diabetes Mellitus, Type 2 - pathology; Female; Humans; Male; Middle Aged; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - physiology; Norepinephrine - pharmacology; Skin - pathology; Stem Cells - pathology; Wound Healing - drug effects; Wound Healing - physiology; skin; progenitor cells; vascular smooth muscle; type-2 diabetes

Objective: Few methods enable molecular and cellular studies of vascular aging or Type 2 diabetes (T2D). Here, we report a new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin. Approach and results: Skin-de...