Tuberculous meningitis in Bacille Calmette-Guerin-vaccinated children: clinical spectrum and outcome

The Bacille Calmette-Guérin vaccination (BCG) contributed widely to reduce tuberculosis incidence in developing countries. The aim of this report was to assess the clinical "spectrum" and outcome of tuberculous meningitis in 16 Bacille Calmette-Guérin-vaccinated Tunisian children. They wer...

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Published inJournal of child neurology Vol. 27; no. 6; p. 741
Main Authors Khemiri, Monia, Bagais, Abderrahmen, Becher, Saayda Ben, Bousnina, Souad, Bayoudh, Fethi, Mehrezi, Ahmed, Lakhoua, Rachid, Barsaoui, Siham
Format Journal Article
LanguageEnglish
Published United States 01.06.2012
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Abstract The Bacille Calmette-Guérin vaccination (BCG) contributed widely to reduce tuberculosis incidence in developing countries. The aim of this report was to assess the clinical "spectrum" and outcome of tuberculous meningitis in 16 Bacille Calmette-Guérin-vaccinated Tunisian children. They were 9 boys and 7 girls aged 2 to 168 months (median 72 months ± 65.88). Patients presented mainly with nonspecific symptoms. Neurologic severity was classified as grade I (n = 6) and grade II or III (n = 10). At short-term course, the majority of patients developed serious complications: hydrocephalus (n = 12), seizures (n = 8), tuberculoma (n = 6), and acute respiratory failure (n = 2). Three patients died. Among survivors, 4 patients showed a complete recovery while 9 developed permanent sequelae which were mild (n = 6) to severe (n = 3). Despite the Bacille Calmette-Guérin vaccination, tuberculous meningitis remains a life-threatening condition; vaccinated children have shown common presentation of tuberculous meningitis in terms of severity and poor outcome.
AbstractList The Bacille Calmette-Guérin vaccination (BCG) contributed widely to reduce tuberculosis incidence in developing countries. The aim of this report was to assess the clinical "spectrum" and outcome of tuberculous meningitis in 16 Bacille Calmette-Guérin-vaccinated Tunisian children. They were 9 boys and 7 girls aged 2 to 168 months (median 72 months ± 65.88). Patients presented mainly with nonspecific symptoms. Neurologic severity was classified as grade I (n = 6) and grade II or III (n = 10). At short-term course, the majority of patients developed serious complications: hydrocephalus (n = 12), seizures (n = 8), tuberculoma (n = 6), and acute respiratory failure (n = 2). Three patients died. Among survivors, 4 patients showed a complete recovery while 9 developed permanent sequelae which were mild (n = 6) to severe (n = 3). Despite the Bacille Calmette-Guérin vaccination, tuberculous meningitis remains a life-threatening condition; vaccinated children have shown common presentation of tuberculous meningitis in terms of severity and poor outcome.
Author Mehrezi, Ahmed
Bousnina, Souad
Bagais, Abderrahmen
Becher, Saayda Ben
Khemiri, Monia
Barsaoui, Siham
Lakhoua, Rachid
Bayoudh, Fethi
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Snippet The Bacille Calmette-Guérin vaccination (BCG) contributed widely to reduce tuberculosis incidence in developing countries. The aim of this report was to assess...
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StartPage 741
SubjectTerms Adolescent
BCG Vaccine - adverse effects
Child
Child, Preschool
Female
Humans
Hydrocephalus - etiology
Infant
Male
Seizures - etiology
Statistics, Nonparametric
Treatment Outcome
Tuberculoma - etiology
Tuberculosis, Meningeal - classification
Tuberculosis, Meningeal - immunology
Tuberculosis, Meningeal - pathology
Tuberculosis, Meningeal - prevention & control
Tunisia
Title Tuberculous meningitis in Bacille Calmette-Guerin-vaccinated children: clinical spectrum and outcome
URI https://www.ncbi.nlm.nih.gov/pubmed/22190501
Volume 27
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