Expression of FoxP3, a key molecule in CD4+CD25+ regulatory T cells, in adult T‐cell leukaemia/lymphoma cells

• Published in: British journal of haematology Vol. 126; no. 1; pp. 81 - 84
• Main Authors: Karube, Kennosuke, Ohshima, Koichi, Tsuchiya, Takeshi, Yamaguchi, Takahiro, Kawano, Riko, Suzumiya, Junji, Utsunomiya, Atae, Harada, Mine, Kikuchi, Masahiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2004; Blackwell
• Subjects: adult T‐cell leukaemia/lymphoma; Biological and medical sciences; CD4+CD25+ T cells; FoxP3; Hematologic and hematopoietic diseases; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; regulatory T cells; Adult T cell leukemia; Hematology; Retroviridae; Malignant hemopathy; Lymphoma; Infection; Virus; regulatory T cells; adult T-cell leukaemia/lymphoma; Lymphoproliferative syndrome; Viral disease; T-Lymphocyte; CD4+CD25+ T cells; HTLV-I virus; FoxP3

Summary Adult T‐cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4+CD25+ phenotype. Regulatory T cells (Treg), which suppress T‐cell effector function, are characterized by the co‐expression of CD4 and CD25. We analysed the expression of forkhead/winged he...