Evaluation of miRNAs regulation of BDNF and IGF1 genes in T2DM insulin resistance in experimental models: bioinformatics based approach

• Published in: Brazilian journal of biology Vol. 84; pp. e256691 - 13
• Main Authors: Freitas, R M, Felipe, S M S, Ribeiro, J K C, Araújo, V R, Martin, C P S, Oliveira, M A F, Martins, S D, Pontes, J P A, Alves, J O, Soares, P M, Ceccatto, V M
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Instituto Internacional de Ecologia 2024
• Subjects: Animal models; Binding sites; Bioinformatics; BIOLOGY; Biomarkers; Brain-derived neurotrophic factor; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Gene expression; Gene regulation; Genes; Glucose; Glucose metabolism; Homology; Insulin; Insulin resistance; Insulin-like growth factor I; Metabolism; MicroRNAs; miRNA; mRNA; Muscles; Musculoskeletal system; Organisms; Pathogenesis; Physiology; Ribonucleic acid; RNA; Skeletal muscle; Therapeutic targets; T2DM; therapeutics; interaction validation; predição de miRNAS; validação de interação; miRNAs prediction; DM2; terapêutica; IGF1/BDNF

microRNAs (miRNAs) are recognized as diabetes mellitus type 2 (T2DM) biomarkers useful for disease metabolism comprehension and have great potential as therapeutics targets. BDNF and IGF1 increased expression are highly involved in the benefits of insulin and glucose paths, however, they are down-re...