RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling

• Published in: Hepatology (Baltimore, Md.) Vol. 77; no. 5; pp. 1670 - 1687
• Main Authors: Zhang, Yanqiu, Ye, Shengtao, Lu, Weijia, Zhong, Jiawen, Leng, Yingrong, Yang, Ting, Luo, Jun, Xu, Wenjun, Zhang, Hao, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.05.2023
• Subjects: Animals; Carcinoma, Hepatocellular - pathology; Choline - metabolism; DEAD-box RNA Helicases - metabolism; Diet, High-Fat - adverse effects; Disease Models, Animal; Inflammation - metabolism; Liver - pathology; Liver Neoplasms - pathology; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - metabolism

Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH. DEAD-box protein 5 (DDX5) plays important...