Hesperetin improves diabetic coronary arterial vasomotor responsiveness by upregulating myocyte voltage‑gated K+ channels

• Published in: Experimental and therapeutic medicine Vol. 20; no. 1; pp. 486 - 494
• Main Authors: Liu, Yu, Zhang, Lei, Dong, Lina, Song, Qiying, Guo, Pengmei, Wang, Yan, Chen, Zhaoyang, Zhang, Mingsheng
• Format: Journal Article
• Language: English
• Published: Athens Spandidos Publications UK Ltd 01.07.2020; D.A. Spandidos
• Subjects: Cellulose; Coronary vessels; Diabetes; Experiments; Glucose; Rodents; Smooth muscle; Veins & arteries

Hesperetin (HSP) is a naturally occurring flavonoid. The present study aimed to investigate the potential vasomotor effects and mechanisms of HSP action on rat coronary arteries (RCAs) injured by diabetes or high glucose concentrations. HSP (100 mg/kg/day) was intragastrically administered to the ra...