Use of protein electrophoresis in the diagnosis of cerebrospinal fluid rhinorrhoea

The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of non-invasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus s...

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Bibliographic Details
Published inJournal of laryngology and otology Vol. 106; no. 6; p. 504
Main Authors Porter, M J, Brookes, G B, Zeman, A Z, Keir, G
Format Journal Article
LanguageEnglish
Published England 01.06.1992
Subjects
Adult
Cerebrospinal Fluid Proteins - analysis
Cerebrospinal Fluid Rhinorrhea - diagnosis
Electrophoresis, Agar Gel
Female
Humans
Male
tau Proteins - analysis
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Summary:The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of non-invasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus saved unnecessary invasive investigations or surgery. A modification of the method of analysis, which improves diagnostic accuracy, is described.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100119991