Thrombin Receptor Activation Inhibits Monocyte Spreading by Induction of ETB Receptor-Coupled Nitric Oxide Release

Abstract The effect of thrombin receptor activation on monocyte conformation was evaluated using the human monocyte cell line, THP-1, and the thrombin mimetic peptide, Trap-14. Treatment of THP-1 cells with Trap-14 induced rapid rounding of ameboid cells adherent to fibronectin-coated slides, wherea...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 161; no. 9; pp. 5039 - 5044
Main Authors Srivastava, Kamal D, Magazine, Harold I
Format Journal Article
LanguageEnglish
Published Am Assoc Immnol 01.11.1998
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