Environmental resistome–guided development of resistance-tolerant antibiotics

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 122; no. 21; p. e2504781122
• Main Authors: Peek, James, Bhattacharjee, Abir, Burian, Ján, Hsieh, David Chun-Cheng, Hernandez, Yozen, Ternei, Melinda, Panfil, Cecilia, Brady, Sean F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.05.2025
• Subjects: Analogs; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Bacteria - drug effects; Bacteria - genetics; Congeners; Drug Resistance, Bacterial - genetics; Lead compounds; Metagenome; Metagenomics; Metagenomics - methods; drug development; resistome; antibiotic resistance; metagenomics

Failure to anticipate new forms of antibiotic resistance has led to resistance developing rapidly to virtually all antibiotics that have entered clinical use. Many of the most problematic types of resistance originated in the environment, where ancient arms races between antibiotic-producing microbe...