Altered myocardial acetylcholine and norepinephrine concentrations in right ventricular hypertrophy and failure

• Published in: Heart and vessels Vol. 6; no. 3; p. 150
• Main Authors: Yamada, Y, Okumura, K, Hashimoto, H, Ito, T, Satake, T
• Format: Journal Article
• Language: English; Japanese
• Published: Japan 01.09.1991
• Subjects: Acetylcholine - physiology; Animals; Cardiomegaly - physiopathology; Heart - innervation; Heart Failure - physiopathology; Hemodynamics - physiology; Hypertension, Pulmonary - chemically induced; Hypertension, Pulmonary - physiopathology; Male; Monocrotaline; Myocardial Contraction - physiology; Norepinephrine - physiology; Rats; Rats, Inbred Strains

The progression of cardiac hypertrophy and failure is associated with marked changes in cardiac autonomic innervation, and there are sympathetic-parasympathetic interactions in the regulation of cardiac function. Although the indexes of sympathetic innervation have been found to be depressed with th...