Prediction of physical aging in controlled-release coatings: the application of the relaxation coupling model to glassy cellulose acetate

• Published in: Pharmaceutical research Vol. 8; no. 6; p. 698
• Main Authors: Sinko, C M, Yee, A F, Amidon, G L
• Format: Journal Article
• Language: English
• Published: United States 01.06.1991
• Subjects: Cellulose - analogs & derivatives; Cellulose - chemistry; Delayed-Action Preparations; Drug Design; Models, Theoretical; Permeability; Polymers; Temperature; Time Factors; Water

The effect of physical aging on both the water transport properties and the mechanical properties of glassy cellulose acetate was investigated. Results indicate a reduction in the mechanical rate of relaxation as well as a reduction in the water permeability as the glass ages. A model which describe...