2,3,7,8-Tetrachlorodibenzo- p  -dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition

• Published in: Archives of toxicology Vol. 71; no. 6; pp. 383 - 400
• Main Authors: Kreuzer, P. E., Csanády, G. A., Baur, C., Kessler, W., Päpke, O., Greim, H., Filser, J. G.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 1997
• Subjects: Adipose Tissue - metabolism; Biological and medical sciences; Body Burden; Breast Feeding; Child, Preschool; Digestive System - drug effects; Digestive System - metabolism; Environmental pollutants toxicology; Feces - chemistry; Female; Fetal Death - metabolism; Food Contamination; General aspects; Humans; Infant; Infant, Newborn; Lipid Metabolism; Liver - drug effects; Liver - metabolism; Medical sciences; Milk, Human - chemistry; Models, Biological; Muscles - drug effects; Muscles - metabolism; Pesticide Residues - adverse effects; Pesticide Residues - blood; Pesticide Residues - metabolism; Pesticide Residues - pharmacokinetics; Polychlorinated Dibenzodioxins - adverse effects; Polychlorinated Dibenzodioxins - blood; Polychlorinated Dibenzodioxins - metabolism; Polychlorinated Dibenzodioxins - pharmacokinetics; Sudden Infant Death; Toxicology; Europe; Germany; Human; Toxicokinetics; Pollutant; Adipose tissue; Liver; Rate; Environment; Infant; Breast feeding; Pharmacokinetics

Contents of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of 16 further congeners--polychlorinated dibenzodioxins and dibenzofuranes (PCDD/PCDF)--were determined in lipids of adipose tissue and of livers of 3 stillborns and of 17 infants (0.43-44 weeks old) who died from sudden infant death syndrom...