Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma

• Published in: Nature communications Vol. 15; no. 1; pp. 5352 - 18
• Main Authors: Lorenzo-Sanz, Laura, Lopez-Cerda, Marta, da Silva-Diz, Victoria, Artés, Marta H, Llop, Sandra, Penin, Rosa M, Bermejo, Josep Oriol, Gonzalez-Suarez, Eva, Esteller, Manel, Viñals, Francesc, Espinosa, Enrique, Oliva, Marc, Piulats, Josep M, Martin-Liberal, Juan, Muñoz, Purificación
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 24.06.2024; Nature Portfolio
• Subjects: Animals; Antitumor activity; B7-1 Antigen - metabolism; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - metabolism; Blocking; Cancer; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; CD80 antigen; Cell Line, Tumor; Cell Plasticity - drug effects; CTLA-4 Antigen - antagonists & inhibitors; CTLA-4 Antigen - immunology; CTLA-4 Antigen - metabolism; CTLA-4 protein; E-cadherin; Epithelial-Mesenchymal Transition - immunology; Head and neck carcinoma; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immune response; Immunosurveillance; Immunotherapy; Immunotherapy - methods; Ligands; Male; Melanoma; Mice; PD-1 protein; PD-L1 protein; Plastic properties; Plasticity; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - metabolism; Receptors, Immunologic - metabolism; Receptors, Virus - genetics; Receptors, Virus - metabolism; Skin Neoplasms - drug therapy; Skin Neoplasms - immunology; Skin Neoplasms - pathology; Skin Neoplasms - therapy; Squamous cell carcinoma; Vimentin

Immune checkpoint blockade (ICB) approaches have changed the therapeutic landscape for many tumor types. However, half of cutaneous squamous cell carcinoma (cSCC) patients remain unresponsive or develop resistance. Here, we show that, during cSCC progression in male mice, cancer cells acquire epithe...