Effects on Neural Function of Repleting Vitamin E–Deficient Rats With α-Tocopherol

• Published in: Journal of neurophysiology Vol. 95; no. 4; pp. 2553 - 2559
• Main Authors: Hayton, Samantha M., Kriss, Tony, Wade, Angie, Muller, David P. R.
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: alpha-Tocopherol - administration & dosage; alpha-Tocopherol - pharmacology; alpha-Tocopherol - therapeutic use; Animals; Disease Models, Animal; Disease Progression; Electrophysiology; Electroretinography; Evoked Potentials, Somatosensory - physiology; Evoked Potentials, Visual - physiology; Longitudinal Studies; Male; Neural Conduction - physiology; Neurons - drug effects; Neurons - physiology; Rats; Rats, Wistar; Reproducibility of Results; Vitamin E Deficiency - drug therapy; Vitamin E Deficiency - physiopathology

A severe and chronic deficiency of vitamin E (α-tocopherol) is associated with a characteristic neurological syndrome with typical “clinical,” neuropathological, and electrophysiological abnormalities in both humans and experimental animals. Repletion of vitamin E–deficient human subjects with α-toc...