Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives

• Published in: BMC nephrology Vol. 26; no. 1; pp. 127 - 14
• Main Authors: Li, Junle, He, Wanhong, Wu, Qianshi, Qin, Yuanyuan, Luo, Changfang, Dai, Zhuojun, Long, Yang, Yan, Pijun, Huang, Wei, Cao, Ling
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.03.2025; BMC
• Subjects: 3-Hydroxybutyric Acid - metabolism; 3-Hydroxybutyric Acid - therapeutic use; Acylation; Animals; Autophagy; Carbohydrates; Diabetes; Diabetes mellitus; Diabetic kidney disease (DKD); Diabetic Nephropathies - diet therapy; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - prevention & control; Diet; Diet, Ketogenic - methods; Diet, Ketogenic - trends; Dietary supplements; Disease prevention; End-stage renal disease; Epilepsy; Fibrosis; G protein-coupled receptors; Glucose metabolism; High carbohydrate diet; High fat diet; Histones; Humans; Hyperlipidemia; Ketogenic diets (KD); Ketones; Kidney diseases; Kidney stones; Lipid metabolism; Lipids; Literature reviews; Low carbohydrate diet; Low fat diet; Medical Subject Headings-MeSH; Metabolism; Nutrient deficiency; Osteoporosis; Oxidative stress; Polycystic ovary syndrome; Side effects; Urine; β-hydroxybutyrate (BHB); Diabetic kidney disease (DKD); Ketogenic diets (KD); β-hydroxybutyrate (BHB)

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease. Ketogenic diets (KD) is a high-fat, low-carbohydrate diet. KD produces ketone bodies to supplement energy in the case of insufficient glucose in the body. β-Hydroxybutyrate (BHB) is the main component of ketone bodies. BHB s...