Stereoselective palladium-catalyzed cross-coupling of (2-amido-1-phenylpropyl)zinc compounds with aryl bromides

• Published in: Chemical research in Chinese universities Vol. 29; no. 4; pp. 678 - 681
• Main Authors: Tang, Shi, Zhou, Dong, Li, Shu-hua, Wang, Nai-xing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2013; College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, P.R.China; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R.China%College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, P.R.China%Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R.China
• Subjects: Analytical Chemistry; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Inorganic Chemistry; Organic Chemistry; Physical Chemistry; Negishi coupling; Palladium; Benzylic zinc; 2-Arylphenylethylamine; Stereoselective

A controllable diastereoselective C( sp 2 )-C( sp 3 ) Negishi coupling reaction of secondary benzylic zinc reagents with aryl bromides to form medicinally important 2-arylphenylethylamines was demonstrated. In the presence of Pd(OAc) 2 and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl(S-phos), ope...