TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential

• Published in: The Journal of pathology Vol. 264; no. 3; pp. 318 - 331
• Main Authors: Mishima, Masako, Takai, Atsushi, Takeda, Haruhiko, Iguchi, Eriko, Nakano, Shigeharu, Fujii, Yosuke, Ueno, Masayuki, Ito, Takahiko, Teramura, Mari, Eso, Yuji, Shimizu, Takahiro, Maruno, Takahisa, Hidema, Shizu, Nishimori, Katsuhiko, Marusawa, Hiroyuki, Hatano, Etsuro, Seno, Hiroshi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2024; Wiley Subscription Services, Inc
• Subjects: Apoptosis; carcinogenesis; Cell cycle; Cell proliferation; Cyclin E; Cyclin-dependent kinase inhibitor p21; G1 phase; Gene set enrichment analysis; GTP-binding protein; Hepatocellular carcinoma; hepatocyte; Hepatocytes; Immortalization; Immunoprecipitation; Inflammation; Liver; Liver cancer; mouse models; NF-κB protein; p53 Protein; Phenotypes; RNA-directed DNA polymerase; Telomerase reverse transcriptase; Telomeres; tert; Transcriptomes; Ubiquitin; Ubiquitination; Up-regulation; mouse models; hepatocyte; carcinogenesis; cell cycle; tert; liver cancer; hepatocellular carcinoma

Telomerase reverse transcriptase (TERT) gene aberration is detectable in >80% of cases with hepatocellular carcinoma (HCC). TERT reactivation is essential for cellular immortalization because it stabilizes telomere length, although the role of TERT in hepatocarcinogenesis remains unelucidated. To...