An Online Failure Detection Method of the Glucose Sensor-Insulin Pump System: Improved Overnight Safety of Type-1 Diabetic Subjects

• Published in: IEEE transactions on biomedical engineering Vol. 60; no. 2; pp. 406 - 416
• Main Authors: Facchinetti, Andrea, Favero, Simone, Sparacino, Giovanni, Cobelli, Claudio
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.02.2013
• Subjects: Algorithms; Blood Glucose Self-Monitoring - instrumentation; Blood Glucose Self-Monitoring - methods; Computer Simulation; Continuous glucose monitoring (CGM); Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Equipment Failure Analysis - methods; Humans; Hypoglycemic Agents - administration & dosage; Insulin; Insulin - administration & dosage; Insulin Infusion Systems; Kalman filter; Kalman filters; parameter estimation; Predictive models; Reproducibility of Results; Sensitivity; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Sugar; Time measurement

Sensors for real-time continuous glucose monitoring (CGM) and pumps for continuous subcutaneous insulin infusion (CSII) have opened new scenarios for Type-1 diabetes treatment. However, occasional failures of either CGM or CSII may expose diabetic patients to possibly severe risks, especially overni...