Hippo/YAP Pathway Plays a Critical Role in Effect of GDNF Against Aβ-Induced Inflammation in Microglial Cells

• Published in: DNA and cell biology Vol. 39; no. 6; p. 1064
• Main Authors: Qing, Jie, Liu, Xiaoheng, Wu, Quan, Zhou, Mengjie, Zhang, Yuwei, Mazhar, Maryam, Huang, Xiaoli, Wang, Li, He, Fuqian
• Format: Journal Article
• Language: English
• Published: United States 01.06.2020
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Amyloid beta-Peptides - pharmacology; Animals; Cell Cycle Proteins - deficiency; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line; Cytokines - biosynthesis; Glial Cell Line-Derived Neurotrophic Factor - pharmacology; Inflammation - metabolism; Inflammation - pathology; Mice; Microglia - drug effects; Microglia - metabolism; Microglia - pathology; Protein-Serine-Threonine Kinases - metabolism; RNA Interference; Signal Transduction - drug effects; glial cell line-derived neurotrophic factor; inflammation; microglia; Hippo/YAP signaling

Neuroinflammation is a critical mechanism responsible for the progression of Alzheimer's disease (AD). Recent studies reveal that Hippo/Yes-associated protein (YAP) signaling pathway is highly associated with a series of inflammation-related disorders. Glial cell line-derived neurotrophic facto...