Antidiabetic and renoprotective effects of Corni Fructus extract in db/db mice
This study investigated the effect of Corni Fructus ( Cornus officinalis Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. Eight weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated di...
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| Published in | Molecular & cellular toxicology Vol. 6; no. 2; pp. 135 - 142 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
The Korean Society of Toxicogenomics and Toxicoproteomics
01.06.2010
대한독성 유전단백체 학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-642X 2092-8467 |
| DOI | 10.1007/s13273-010-0020-7 |
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| Abstract | This study investigated the effect of Corni Fructus (
Cornus officinalis
Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. Eight weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Final fasting serum glucose level in the DCF group was significantly lower than the DC group by 32% (
P
<0.05). Urine 24-h volume and urine total protein in the DCF group were significantly lower (
P
<0.05) than the DC group by 53% and 88%, respectively. The mRNA expression of angiotensin II, collagen I, collagen IV and TGF-β
1
in kidneys were significantly lower (
P
<0.05 or
P
<0.01) in the DCF group than the DC group by 39%, 42%, 38% and 26%, respectively. In histological staining of kidney tissues, collagen deposition was markedly reduced in the DCF group compared to the DC group. Immunohistochemical staining for TGF-β
1
in kidneys of the DCF group was more mildly expressed than the DC group. In conclusion, these results indicate that Corni Fructus can be effective on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. |
|---|---|
| AbstractList | This study investigated the effect of Corni Fructus (
Cornus officinalis
Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. Eight weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Final fasting serum glucose level in the DCF group was significantly lower than the DC group by 32% (
P
<0.05). Urine 24-h volume and urine total protein in the DCF group were significantly lower (
P
<0.05) than the DC group by 53% and 88%, respectively. The mRNA expression of angiotensin II, collagen I, collagen IV and TGF-β
1
in kidneys were significantly lower (
P
<0.05 or
P
<0.01) in the DCF group than the DC group by 39%, 42%, 38% and 26%, respectively. In histological staining of kidney tissues, collagen deposition was markedly reduced in the DCF group compared to the DC group. Immunohistochemical staining for TGF-β
1
in kidneys of the DCF group was more mildly expressed than the DC group. In conclusion, these results indicate that Corni Fructus can be effective on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. This study investigated the effect of Corni Fructus (Cornus officinalis Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. Eight weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Final fasting serum glucose level in the DCF group was significantly lower than the DC group by 32% (P⁄0.05). Urine 24-h volume and urine total protein in the DCF group were significantly lower (P⁄0.05) than the DC group by 53% and 88%, respectively. The mRNA expression of angiotensin II, collagen I, collagen IV and TGF-β1 in kidneys were significantly lower (P⁄0.05 or P⁄0.01) in the DCF group than the DC group by 39%, 42%, 38% and 26%, respectively. In histological staining of kidney tissues, collagen deposition was markedly reduced in the DCF group compared to the DC group. Immunohistochemical staining for TGF-β1 in kidneys of the DCF group was more mildly expressed than the DC group. In conclusion, these results indicate that Corni Fructus can be effective on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. KCI Citation Count: 7 |
| Author | Kim, Young-Chul Kim, Hye-Jeong |
| Author_xml | – sequence: 1 givenname: Hye-Jeong surname: Kim fullname: Kim, Hye-Jeong email: yckim@kmu.ac.kr organization: Department of Public Health, Keimyung University, Division of Human Blood Safety Surveillance, Korea Centers for Disease Control & Prevention – sequence: 2 givenname: Young-Chul surname: Kim fullname: Kim, Young-Chul organization: Department of Public Health, Keimyung University |
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| CitedBy_id | crossref_primary_10_1007_s00580_012_1639_7 crossref_primary_10_1007_s12257_013_0444_8 crossref_primary_10_1016_j_biopha_2017_09_135 crossref_primary_10_5487_TR_2015_31_2_165 crossref_primary_10_1080_10286020_2018_1497609 crossref_primary_10_5487_TR_2011_27_1_037 crossref_primary_10_1039_C8RA06045B crossref_primary_10_1002_ptr_5529 crossref_primary_10_3390_plants10112347 |
| Cites_doi | 10.2337/diabetes.46.3.473 10.2337/diabetes.52.4.1031 10.1053/anep.2003.50017 10.1002/(SICI)1099-0895(199612)12:4<309::AID-DMR171>3.0.CO;2-A 10.2337/diabetes.41.6.679 10.1021/jf000167b 10.1016/j.diabres.2007.08.009 10.1002/bmc.247 10.1016/j.phymed.2006.03.023 10.1248/bpb.30.520 10.1016/S0378-8741(02)00355-0 10.1111/j.1523-1755.2005.00158.x 10.1006/abio.1993.1588 10.1038/ki.1991.57 10.1161/CIRCULATIONAHA.105.563213 10.2337/diabetes.40.4.405 10.1046/j.1523-1755.1998.00127.x 10.1172/JCI112521 10.3121/cmr.1.1.13 10.1016/S1056-8727(00)00124-0 10.1046/j.1523-1755.1999.00721.x 10.2337/diabetes.48.10.2066 10.1016/j.jep.2006.01.012 10.1248/bpb.31.1422 10.1159/000066656 10.1053/snep.2003.50017 10.1093/geronj/12.2.166 10.2337/diab.40.4.405 10.1093/clinchem/29.8.1494 10.2337/diab.46.3.473 10.1002/ptr.3101 10.2337/diab.41.6.679 10.1097/00041552-199707000-00014 |
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| Keywords | Fibrosis progress Diabetic nephropathy Corni Fructus db/db mice |
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doi: 10.2337/diab.40.4.405 – volume: 17 start-page: 306 year: 2003 ident: 20_CR26 publication-title: Biomed Chromatogr doi: 10.1002/bmc.247 – volume: 54 start-page: 1390 year: 1998 ident: 20_CR24 publication-title: Kidney Int doi: 10.1046/j.1523-1755.1998.00127.x – volume: 29 start-page: 1494 year: 1983 ident: 20_CR32 publication-title: Clin Chem doi: 10.1093/clinchem/29.8.1494 – volume: 14 start-page: 250 year: 2000 ident: 20_CR18 publication-title: J Diabetes Complication doi: 10.1016/S1056-8727(00)00124-0 – volume: 215 start-page: 284 year: 1993 ident: 20_CR31 publication-title: Anal Biochem doi: 10.1006/abio.1993.1588 – volume: 46 start-page: 473 year: 1997 ident: 20_CR6 publication-title: Diabetes doi: 10.2337/diab.46.3.473 – volume: 93 start-page: 3 year: 2003 ident: 20_CR9 publication-title: Nephron Physiol doi: 10.1159/000066656 – volume: 79 start-page: 11 year: 2008 ident: 20_CR22 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2007.08.009 – ident: 20_CR27 doi: 10.1002/ptr.3101 – volume: 25 start-page: 1 year: 2009 ident: 20_CR19 publication-title: Evid Based Complement Alternat Med – volume: 12 start-page: 309 year: 1996 ident: 20_CR5 publication-title: Diabetes Metab Rev doi: 10.1002/(SICI)1099-0895(199612)12:4<309::AID-DMR171>3.0.CO;2-A – volume: 85 start-page: 1 year: 2003 ident: 20_CR15 publication-title: J Ethnopharmacol doi: 10.1016/S0378-8741(02)00355-0 – volume: 41 start-page: 679 year: 1992 ident: 20_CR3 publication-title: Diabetes doi: 10.2337/diab.41.6.679 – volume: 6 start-page: 389 year: 1997 ident: 20_CR23 publication-title: Curr Opin Nephrol Hypertens doi: 10.1097/00041552-199707000-00014 – volume: 67 start-page: 944 year: 2005 ident: 20_CR25 publication-title: Kidney Int doi: 10.1111/j.1523-1755.2005.00158.x – volume: 63 start-page: S195 year: 1997 ident: 20_CR21 publication-title: Kidney Int Suppl |
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| Snippet | This study investigated the effect of Corni Fructus (
Cornus officinalis
Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy... This study investigated the effect of Corni Fructus (Cornus officinalis Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in... |
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| StartPage | 135 |
| SubjectTerms | Biomedical and Life Sciences Cell Biology Life Sciences Original Paper Pharmacology/Toxicology 생물학 |
| Title | Antidiabetic and renoprotective effects of Corni Fructus extract in db/db mice |
| URI | https://link.springer.com/article/10.1007/s13273-010-0020-7 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001738051 |
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| ispartofPNX | Molecular & Cellular Toxicology, 2010, 6(2), , pp.135-142 |
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