A prospective study of pyrogenic reactions in hemodialysis patients using bicarbonate dialysis fluids filtered to remove bacteria and endotoxin

• Published in: Journal of the American Society of Nephrology Vol. 3; no. 4; pp. 1002 - 1007
• Main Authors: Pegues, D A, Oettinger, C W, Bland, L A, Oliver, J C, Arduino, M J, Aguero, S M, McAllister, S K, Gordon, S M, Favero, M S, Jarvis, W R
• Format: Journal Article
• Language: English
• Published: United States 01.10.1992
• Subjects: Adult; Aged; Aged, 80 and over; Bacteria - isolation & purification; Bicarbonates - administration & dosage; Cohort Studies; Drug Contamination; Endotoxins - analysis; Equipment Contamination; Female; Fever - epidemiology; Fever - etiology; Fever - prevention & control; Filtration; Hemodialysis Solutions - adverse effects; Hemodialysis Solutions - standards; Humans; Incidence; Male; Membranes, Artificial; Middle Aged; Polymers; Prospective Studies; Renal Dialysis - adverse effects; Renal Dialysis - instrumentation; Sterilization; Sulfones

Pyrogenic reactions (PR) are a well-recognized complication of hemodialysis and have been associated with dialyzer reuse, high-flux dialysis, and bicarbonate dialysate. However, the roles of bacteria and endotoxin in dialysate for producing PR are not well defined. To determine the effect of removin...